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 Livingston, N.J.--A clinical research study investigating genetic predisposition to colon tumors is currently underway at Saint Barnabas Medical Center, in collaboration with Cancer Research UK, a prominent British research and science organization in England.
New research has recently shown that many people who develop colon polyps or colon cancer have an inherited predisposition for the development of these tumors. Five recent genetic variations have been identified over the last few years. With continued research, additional genetic changes may be identified in the future.
The study intends to establish the incidence of these genetic changes in the New Jersey area population and determine their possible contribution to the formation of tumors. In addition, this research will expand current knowledge about the significance of these mutations and their implication for prevention strategies. Researchers also hope the study will assist with efforts to identify additional mutations.
“In the course of our research at Saint Barnabas, we have been fortunate to participate in the identification of two gene mutations that contribute to the development of colorectal polyps and cancer. We were able to identify suitable individuals whose tissue analyses contributed to the identification of these mutations,” said Peter Zauber, M.D., Section Chief of Hematology at Saint Barnabas and a principle investigator of the study.
If you are a member of the Ashkenazi Jewish population (thus far the genetic changes being studied have only been found in those of Jewish heritage), are over age 50 and have had a colonoscopy within the last five years, you may be eligible to participate. A family or personal history of colon cancer is not necessary for inclusion in the study.
Those who join the study will be asked to answer questions during a short telephone interview and provide a sample of blood if no tissue is available.
If you meet these criteria and are interested in participating, please call Maryann Larangera at Saint Barnabas Medical Center at
(973) 322-5771. All testing is free of charge and strictly confidential.
Date: May, 2005
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